Advanced LNP & Nanomedicine Evaluation

JOANNEUM RESEARCH HEALTH accelerates the development of innovative nanomedicines by providing specialized solutions for the preclinical evaluation, bioanalysis, and in-vivo tracking of Lipid Nanoparticles (LNPs). We help biotech partners optimize formulation performance and validate tissue-specific delivery.

Core Services & Applications

• In-Vivo Biodistribution & Tissue Targeting: Quantitative tracking of LNPs in specific target tissues (e.g., brain, skin, adipose tissue) utilizing our proprietary Open Flow Microperfusion (OFM) technology.

• Blood-Brain Barrier (BBB) Penetration: Utilizing cOFM to directly measure the efficiency of surface-engineered LNPs in crossing the intact blood-brain barrier into the interstitial fluid of the brain.

• High-End Lipid Analytics: GLP-compliant quantification of individual lipid components (e.g., ionizable lipids, helper lipids, cholesterol, and PEG-lipids) in biological matrices using advanced LC-MS/MS.

• Cargo-Agnostic PK/PD Profiling: Simultaneous monitoring of vehicle stability and active ingredient release directly at the site of action.