Tissue specific PK/PD

JOANNEUM RESEARCH HEALTH offers Open Flow Microperfusion (OFM), a patented, minimal-invasive technology for continuous, probe-based sampling directly from the interstitial fluid of targeted tissues. OFM provides unfiltered, diluted samples containing the full spectrum of substances (including large molecules and lipophilic drugs) without tissue distortion.

Core Services & Applications

• cOFM (Cerebral OFM): Continuous monitoring of drug transport across the intact blood-brain barrier (BBB). Ideal for PK/PD profiling of neuropharmaceuticals in the brain.

• aOFM (Dermal/Adipose OFM): Direct assessment of bioequivalence, pharmacokinetics, and metabolism of topical or subcutaneous drugs in skin and adipose tissue.

• Translational 3R/NAMs Solutions: High-precision intratarget microdosing (ITM) and advanced tissue models to maximize data relevance while reducing animal testing.